Perception of Signals by Biological Membranes: Sensor Proteins and Expression of Genes

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چکیده

Самые разные изменения в окружающей среде, в режиме питания, возрастные изменения метаболизма, опухолевые заболевания, инфекции приводят к изменениям в структуре мембран, которые, в свою очередь, вызывают нарушения нормального функционирования клеток. Поэтому изучение структуры мембран привлекает к себе внимание исследователей. Мембраны обладают свойством текучести, которая, изменяясь под действием различных физических и химических воздействий, обеспечивает адаптивные перестройки в мембране и изменение активности мембраносвязанных белков, воспринимающих и передающих внешние сигналы. К числу таких молекул относятся рецепторные протеинкиназы и другие сенсоры, ионные каналы, белки – переносчики различных молекул. Изменение функционального состояния сенсорных белков влияет на экспрессию генов, отвечающих за адаптацию клеток к стрессовым условиям.

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تاریخ انتشار 2002